Akka.NET is used by many large organizations in a big range of industries all from investment and merchant banking, retail and social media, simulation, gaming and betting, automobile and traffic systems, health care, data analytics and much more. Any system that have the need for high-throughput and low latency is a good candidate for using Akka.NET.
There is a great discussion on use-cases for Akka.NET with some good write-ups by production users here
Transaction processing (Online Gaming, Finance/Banking, Trading, Statistics, Betting, Social Media, Telecom)
Service backend (any industry, any app)
Sam Covington, IVC Business Systems: We had an in-house "Actor" system that we replaced with Akka.Net, which allowed us to innovate and be productive elsewhere, and not reinvent the wheel(not to mention test it to death). This back end of Microservices forms the basis of all of our products and services. We're using it in our Enterprise Social Product, and our new Livescan Office product for Livescan fingerprinting customers.
Concurrency/parallelism (any app)
Master/Worker, Compute Grid, MapReduce etc.
Batch processing (any industry)
Camel integration to hook up with batch data sources Actors divide and conquer the batch workloads
Communications Hub (Telecom, Web media, Mobile media)
Gaming and Betting (MOM, online gaming, betting)
Scale up, scale out, fault-tolerance / HA